Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of conical microneedles array using photolithography

Background and Aim: Microneedle technology has led to huge changes in the field of drug delivery medicine. Using microneedles, the drug can be injected locally, painlessly, and in very low and controlled doses with high precision. Local drug delivery through the skin with microneedles has many advantages over other methods of drug delivery. In this method, the drug does not enter the gastrointe...

Design and Fabrication of Plasma Array Antenna with Beam Forming

In this paper, the design and implementation of plasma antenna array with beam forming is discussed. The structure consists of a circular array of plasma tube enclosed in a unipolar UHF band monopole antenna. Beam forming is possible by stimulated plasma tubes. The combination of the above antenna with plasma excitation controller makes a beam forming smart antenna. An experimental model in UHF...

Fabrication and use of microenvironment microarrays (MEArrays).

The interactions between cells and their surrounding microenvironment have functional consequences for cellular behaviour. On the single cell level, distinct microenvironments can impose differentiation, migration, and proliferation phenotypes, and on the tissue level the microenvironment processes as complex as morphogenesis and tumorigenesis(1). Not only do the cell and molecular contents of ...

Microarraying the cellular microenvironment

The in vivo stem cell microenvironment or niche is composed of an intricate blend of extracellular matrix proteins, soluble protein factors, immobilized protein factors, proteoglycans, small molecule signals, in some cases mineralized tissue, and numerous adjacent cell types, all of which likely vary in space and time. In concert, these many components present the cells with an ‘array’ of bioch...

Patterning the cellular microenvironment.